Journal article
Social relationships and epigenetic markers of aging in middle-aged and older adults: cross-sectional and prospective analyses
DL Li, X Xu, AM Hodge, MC Southey, GG Giles, RL Milne, PA Dugué
Journals of Gerontology - Series B Psychological Sciences and Social Sciences | Oxford University Press | Published : 2025
Abstract
Objectives Social relationships play an important role in maintaining physical and psychological health. Epigenetic age is a potential mechanism underlying health-related aspects of social relationships. We aimed to assess the cross-sectional and prospective associations of social relationships and epigenetic age in middle-aged and older adults. Methods Blood DNA methylation data were collected from 6,208 participants in the Melbourne Collaborative Cohort Study at baseline (1990-1994, mean age = 59) and 1,110 at follow-up (2003-2007, mean age = 69). Four epigenetic aging measures were considered: PCPhenoAge, PCGrimAge, bAge, and DunedinPACE. Social relationship variables were collected via s..
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Awarded by Cancer Council Victoria